Glioblastoma multiforme (GBM) are the most common and most deadly brain tumors found in adults. In fact, most patients diagnosed with GBM survive only a year after diagnosis. These tumors have the ability to spread very quickly to other areas of the brain, which is one of the reasons why GBM is so difficult to treat.
While over the past 30 years there has been progress in terms of more accurate surgical removal of brain tumors, there has been no improvement in patient survival rates. If any of the cancer cells escape surgical removal, they repopulate and spread into healthy brain tissue.
Researchers at TGen are now trying to understand the genetic mechanisms behind these aggressive and invading cells. Researchers are focused on a gene called Fn14, which is associated with inhibiting cell death in normal cells. This gene is allowing researchers a better understanding of the biological pathways associated with this type of cancer. This understanding is very important to help find therapeutic compounds for better treatments. TGen investigators are also looking at genes that predict how malignant brain tumors respond to therapy.
TGen's Neurogenomics Division
Dr. Eric Reiman
Brain Tumor Research Lab at TGen
Dr. Michael Berens
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