Bipolar disorder is a brain disorder characterized by extreme or unusual shifts in a person's mood, energy, and ability to function. Bipolar disorder affects approximately 1% of the population, and more than 2 million American adults have bipolar disorder.
Research has proven that bipolar disorder has a clear and recognized genetic component. However, the mode of inheritance of bipolar disorder is complex and likely to involve multiple genes.
Investigators at TGen are using genome-wide association studies to identify the most common mutations (changes or similarities from person to person) that lead to sporadic bipolar disorder. By sifting through hundreds of thousands of unique genetic "markers" or signatures across the genome, researchers can identify genes containing common predisposing mutations. Once these genes have been identified, it is possible to translate these discoveries into new therapeutics and treatment options.
Neurobehavioral Research Unit at TGen
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