Adrenocortical Carcinoma (ACC)
Adrenocortical carcinoma (ACC) is a deadly rare cancer of the adrenal cortex, the outside layer of the adrenal glands which are located above each kidney. Tumors of the adrenal cortex may overproduce hormones, resulting in symptoms such as high blood pressure, weight gain, or diabetes.
TGen is currently leading the largest genomic ACC research project to date. There is only one drug on the market approved for the disease. In the past 40 years, little progress has been made toward finding an effective treatment for ACC, which is why the TGen study is so significant. Because ACC is so rare—it strikes only one or two people in a million—it is often difficult to collect enough tumor samples to analyze.
The research program at TGen, headed by Kim Bussey, Ph.D. and Michael Demeure, M.D., is currently analyzing ACC tumors, benign adrenal tumors, and normal tissue with several genomic technologies. TGen researchers will then use the genomic data to identify mutations and design new diagnostic tools and therapeutics to combat this aggressive cancer.
Through U.S. and global research collaborations, including Arizona, Minnesota, Canada, Australia and Germany, and individual patient tumor donations, TGen has already collected more than 40 tumor samples, which are currently being analyzed. Along with the support of Jeffrey Trent, Ph.D. and Daniel Von Hoff, M.D., the ACC project has collaborations with the University of Arizona, the Critical Path Institute, Mayo Clinic Rochester, New York University, and the American Association of Endocrine Surgeons.
The ongoing ACC research project at TGen is aimed at utilizing the most up to date genomic technologies to determine more effective treatments for this rare and devastating cancer.
Advancing Treatments for Adrenocortical Carcinoma video
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Dr. Michael J. Demeure
Dr. Kimberly J. Bussey
Critical Path Institute
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