Ways To Help Skip Navigation Links

Research Skip Navigation Links

About TGen Foundation Skip Navigation Links

TGen News

TGen Web Site

Adrenocortical Carcinoma (ACC)

Adrenocortical carcinoma (ACC) is a deadly rare cancer of the adrenal cortex, the outside layer of the adrenal glands which are located above each kidney. Tumors of the adrenal cortex may overproduce hormones, resulting in symptoms such as high blood pressure, weight gain, or diabetes.

TGen is currently leading the largest genomic ACC research project to date. There is only one drug on the market approved for the disease. In the past 40 years, little progress has been made toward finding an effective treatment for ACC, which is why the TGen study is so significant. Because ACC is so rare—it strikes only one or two people in a million—it is often difficult to collect enough tumor samples to analyze.

The research program at TGen, headed by Kim Bussey, Ph.D. and Michael Demeure, M.D., is currently analyzing ACC tumors, benign adrenal tumors, and normal tissue with several genomic technologies. TGen researchers will then use the genomic data to identify mutations and design new diagnostic tools and therapeutics to combat this aggressive cancer.

Through U.S. and global research collaborations, including Arizona, Minnesota, Canada, Australia and Germany, and individual patient tumor donations, TGen has already collected more than 40 tumor samples, which are currently being analyzed. Along with the support of Jeffrey Trent, Ph.D. and Daniel Von Hoff, M.D., the ACC project has collaborations with the University of Arizona, the Critical Path Institute, Mayo Clinic Rochester, New York University, and the American Association of Endocrine Surgeons.

The ongoing ACC research project at TGen is aimed at utilizing the most up to date genomic technologies to determine more effective treatments for this rare and devastating cancer.


CANCER PROGRAMS Skip Navigation Links
Adrenocortical Cancer
Brain Tumors
Breast Cancer
Colon Cancer
Liver Cancer
Lung Cancer
Ovarian Cancer
Pancreatic Cancer
Prostate Cancer


Advancing Treatments for Adrenocortical Carcinoma video
Low res. | High res.
(Quicktime Player required).

Your donation in support of the ATAC Fund is important to furthering the research of TGen scientists.

Learn more about the ATAC Fund...

Dr. Michael J. Demeure

Dr. Kimberly J. Bussey

Critical Path Institute

Volunteer! Become a TGen Ambassador and help raise funds in your community for Adrenocortical Carcinoma research.

To discuss ways to become involved and support cancer research at TGen, contact the TGen Foundation at Foundation@tgen.org, or call 602.343.8411.